The San Francisco 49ers have a primetime opportunity to get their first win of the season against the Los Angeles Rams on "Thursday Night Football". The Week 3 matchup features the return of the 49ers black alternate jerseys as a part of the NFL's color rush campaign.

If the 49ers are to get their fourth straight against the Rams, the offense will have to find its stride for the first time this season. San Francisco is still looking for its first touchdown of 2017 after being limited to four field goals through two games.

Keep it here throughout Thursday night's contest for play-by-play, highlights and observations.

PREGAME

The 49ers will be without Eric Reid in Week 3 which means that Jaquiski Tartt will start at strong safety. Tartt (neck) entered the game as questionable so having him active is good news for San Francisco. Jimmie Ward (hamstring) will start at free safety. After playing 38 snaps in his 2017 debut last week, expect to see Ward play a bigger role on Thursday.

Also active for the 49ers is linebacker Eli Harold (foot), who like Tartt, was listed as questionable going into the game. Joe Staley, DeForest Buckner and Dekoda Watson are San Francisco's Week 3 captains.

Here are San Francisco's inactives: Reid, Reuben Foster, Kendrick Bourne, Ahkello Witherspoon, Pita Taumoepenu, Erik Magnuson and Xavier Cooper.

And for the Rams: Brandon Allen, Kayvon Webster, Malcolm Brown, Marqui Christian, Ejuan Price, Andrew Donnal and Cornelius Lucas.

FIRST QUARTER

For the first time this season, the 49ers offense got the ball to start the game.

Pierre Garçon threw an interception on the first play from scrimmage by Nickell Robey. The Rams cornerback returned it all the way to the 49ers 3-yard line.

Todd Gurley ran it in on the very next play to put the Rams up early, 7-0. (14:48)

Hyde gave the 49ers a bit of life on the next drive. His second carry went for 20 yards. The Rams declined a holding penalty to set up 3rd-and-10. Hoyer completed a 8-yard pass to George Kittle but the 49ers were still forced to punt it away. San Francisco caught a huge break when the Rams jumped offsides on the ensuing punt to give the 49ers a fresh set of downs.

A third-down pass to Matt Breida gained 12 yards and gave the 49ers another first down. Raheem Mostert followed with two carries for nine yards, and Hyde followed with a 2-yard run to get another first down.

Hoyer gave the 49ers their first touchdown of the season on a 9-yard touchdown run to the right pylon to tie the game, 7-7. (8:17)

That was Hoyer's second-career touchdown run and his first since his rookie season in 2009.

Elvis Dumervil's 100th career sack was wiped out by a holding penalty against Dontae Johnson. Jared Goff followed with a nice sideline throw to Robert Woods for a gain of 31 yards. Goff then completed a 17-yard pass to tight end Derek Carrier.

Gurley found the end zone for the second time of the first quarter, a 7-yard touchdown pass from Goff to put the Rams back on top, 14-7. (4:32)

Gurley now has five touchdowns already on the year.

A 10-yard run by Breida was followed by a 30-yard pass to Pierre Garçon. Mostert fumbled the ball two plays later, and the Rams recovered.

Gurley gained 15 yards on two carries before Goff completed a 21-yard pass to Woods to the 49ers 32-yard line. A short screen pass set up 4th-and-8 to close out the first quarter.

SECOND QUARTER

Greg Zuerlein came onto the field for a long field-goal attempt.

Zuerlein drilled the 48-yarder to put the Rams up 17-7. (14:55)

Hyde returned to the game after being examined for a hip injury. Hoyer's first-down pass missed an open Garçon down the left sideline. An 18-yard pass on third down gave the 49ers a first down at midfield. The drive stalled there. San Francisco caught another huge break as the Rams fumbled a punt. The 49ers recovered, setting up 1st-and-10 from the Rams 12-yard line.

A false start against Joe Staley was followed by a holding penalty on Kyle Juszczyk. Kittle then dropped a pass that would have made it a manageable third down. Instead, the 49ers ran it on 3rd-and-18 to set up a field-goal attempt.

Robbie Gould was good from 36 yards out to make it 17-10, Rams. (9:37)

Gould is now a perfect 5-for-5 on the season.

Tartt dropped Gurley for a 2-yard loss on a short pass into the left flat. Goff followed with two incompletions as Los Angeles went three-and-out.

Hoyer opened the 49ers next drive with a 34-yard pass up the right seam to Juszczyk. On 3rd-and-17, Hoyer found Garçon up the first sideline for an 18-yard gain to move the sticks. On the play, Garçon shed a tackle and lunged for an extra yard to get the first down. The drive stalled at the Rams 30-yard line when Hoyer was sacked on third down.

Gould drilled a 48-yard field goal to pull San Francisco closer, 17-13. (3:46)

The 49ers kicker is now a perfect 6-for-6 on field-goal attempts this season.

Two passes from Goff to Sammy Watkins got Los Angeles moving again. The second was a deep crossing route for a gain of 22 yards to the 49ers 37-yard line. K'Waun Williams broke up a deep pass down the right sideline to Cooper Kupp at the last second. Kupp had Williams beat initially, but the corner recovered nicely. Kupp came right back with a catch on 4th-and-3 to the 49ers 17-yard line. A personal foul against Ward gave the Rams 1st-and-goal from the 49ers 2-yard line.

Gurley scored for the third time, a 2-yard run just before halftime to make it 24-13, Rams. (0:49)

After giving up just 13 points against Seattle, the Rams have almost doubled that total in just two quarters.

Zuerlein's kickoff went out of bounds to give the 49ers great field position at their own 40-yard line. Hoyer got sacked on third down as the teams went into the locker room with the Rams leading, 24-13.

THIRD QUARTER

Goff opened up the second half with a 48-yard completion down the left sideline to Watkins. It was an absolutely perfect pass over Watkins' shoulder. Goff has played extremely well throughout the game, showing he's a much different player than he was a year ago. A pass interference penalty in the end zone against Rashard Robinson gave Los Angeles the ball at the 49ers 1-yard line. San Francisco stuffed Gurley twice at the goal line to force a field-goal attempt.

Zuerlein made a 19-yarder to extend Los Angeles' lead, 27-13. (9:17)

The Rams have 253 yards of total offense.

Garçon made an incredible sideline catch that was initially called incomplete. Upon review, it was determined that Garçon drug both feet for a gain of 19 yards. A 15-yard penalty was tacked on to the end of the play for roughing the passer. Hyde followd with two carries for 18 yards to the Rams 23-yard line.

On 3rd-and-10, Aldrick Robinson gained 18 yards down the middle to set up 1st-and-goal from the Rams 6-yard line. Robinson used a hesitation move against the man in coverage before turning toward the middle of the field.

On 4th-and-1 from the goal line, Hyde plunged into the end zone to make it a one-score game, 27-20, Rams. (5:40)

That was Hyde's first touchdown of the season.

A 15-yard pass to Watkins on third down moved the chains for Los Angeles. Robinson was then flagged for illegal use of hands and gave the Rams a free first down. Goff found Woods for a 25-yard gain with the receiver getting much of that after the catch. That set up 1st-and-goal from the 49ers 9-yard line. Tartt was injured on the play and was tended to by the 49ers medical staff. Tavon Austin ran the ball eight yards to the 1-yard line. A personal foul for a horse collar tackle moved it closer and gave Los Angeles a first down.

After stuffing Gurley twice, Goff hit Watkins on a quick slant for a 1-yard touchdown to put the Rams up 34-20. (0:17)

Goodwin hauled in a 50-yard bomb at the end of the half in double coverage to get the 49ers back into Rams territory at the 25-yard line.

FOURTH QUARTER

Some injury updates: Kyle Juszczyk will not return with a neck injury. Brock Coyle and Tartt are out with head injuries.

Hyde gained five yards on the first play of the fourth quarter. A 3-yard run set up 3rd-and-2. A completion to Hyde gained four yards and moved the sticks. An 11-yard pass to Taylor set up 1st-and-goal from the Rams 1-yard line. Taylor made a man miss on his way towards the goal line.

Hoyer found Garrett Celek for a 1-yard touchdown to make it 34-26, Rams. (12:50)

Gould missed the PAT to keep the margin at eight points.

A 29-yard run by Gurley got the Rams moving immediately. Garrett Celek went down injured following a short run by Gurley. A 27-yard pass to Gurley converted a 3rd-and-10 situation for the Rams.

Goff found Watkins for another touchdown, this time a 13-yard connection to make it 41-26, Rams. (8:43)

Goff's updated line: 22-of-27 passing for 292 yards and three touchdowns.

The 49ers got one first down due to penalty but the offense stalled from there, punting it back to the Rams.

Los Angeles went three-and-out and punted it back to San Francisco.

Hoyer unloaded a 59-yard bomb to Garçon, who is up to six catches for 135 yards. It was a beautiful throw from Hoyer and an incredible diving catch from Garçon.

Three plays later, Hoyer completed a 1-yard touchdown to Taylor to make it 41-33, Rams. (5:08)

That was Taylor's first-career touchdown catch.

Los Angeles fumbled the ensuing kickoff and the 49ers recovered. San Francisco got the ball back with under five minutes remaining, down eight points.

Hoyer began marching the 49ers offense down the field once again. Goodwin made an incredible toe-tapping catch to give the 49ers 1st-and-goal from the Rams 3-yard line.

Hyde scored from 1-yard out to make it 41-39. Hoyer's pass to Taylor on the two-point try was intercepted. (2:13)

While the comeback was exciting, the 49ers used two costly timeouts.

This game continues to get more ridiculous by the second, and I can't keep up. The 49ers recovered an onside kick to give them the ball back with just over two minutes remaining.

Trent Taylor was called for offensive pass interference on a completion that would have netted the 49ers a first down. Looking at the replay, it was an incredibly soft call. Hoyer was ultimately sacked on fourth down to ruin the 49ers chances at a comeback.

Los Angeles holds on, 41-39. San Francisco is now 0-3 on the season. What a fantastic game. Unfortunately, the officiating had a remarkable impact. Goodnight one, goodnight all. Thanks for following along.