EAST RUTHERFORD, N.J. -- We are on the scene at "Sunday Night Football" to bring you the latest updates from the San Francisco 49ers Week 5 matchup with the New York Giants.

Let it begin.

Pregame Notes

Two of San Francisco's inactive players were known well before kick off. Vernon Davis was ruled out on Friday due to a knee injury. In addition, it was known that Ahmad Brooks would miss the game due to a death in the family.

San Francisco announced a pair of lineup changes: Garrett Celek will start for Davis; Corey Lemonier will start for Brooks. Joe Staley missed practice this week with a knee injury, but the four-time Pro Bowl tackle will make his 69th consecutive start. Andrew Tiller, who was promoted to the active roster on Saturday, was also among the 46 dressed players for the 49ers.

Other inactive players for San Francisco included wide receiver DeAndrew White, running back Mike Davis, recently acquired linebacker Gerald Hodgers, offensive lineman Ian Silberman and nose tackle Mike Purcell.

For New York, linebackers Devon Kennard and Jonathan Casillas, tackle Bobby Hart, wide receiver Victor Cruz, tight end Jerome Cunningham, defensive ends Robert Ayers and George Selvie were listed as inactive.

With Kennard and Ayers out, the Giants were without two starters in their front seven. Linebacker Mark Herzlich was named the starter for Kennard; Jay Bromely got the nod at left defensive tackle in the place of Cullen Jenkins, who moved over to defensive end to replace Ayers.

San Francisco Giants second baseman (and NY native) Joe Panik was on the field pregame. The World Series champion and All-Star posted this:

First Quarter

The 49ers won the toss and elected to receive. The offense opened with a three-tight end set and a Pierre Garçon rush of five yards. On the next play, Colin Kaepernick connected on a quick-screen pass to Bruce Ellington for a 30-yard gain down to New York's 45-yard line. Jon Beason later collided with Hyde on a helmet-to-helmet hit. The Giants linebacker was shaken up on the play and was replaced by Uani 'Unga. After building some early momentum, a third-down rush by Reggie Bush went for a 1-yard loss. As a result, Phil Dawson came on the field and connected on a 43-yard field goal. Dawson capped an 8-play, 55-yard scoring drive that took 3:41 off the clock. Hyde rushed for 17 yards on four carries. Ellington caught two passes for 39 yards on the drive.

The early scoring drive earned this reaction from the ambassador of the Bay Area:

49ers lead 3-0 with 11:25 left in the first quarter

New York announced Beason was being evaluated for a possible concussion. Eli Manning wasted no time finding his favorite target. The Giants quarterback launched a deep ball to Odell Beckham Jr. for a gain of 49. Kenneth Acker did a nice job of tracking down the wideout in the open field and bringing him down at San Francisco's 12-yard line. The 49ers dusted themselves off and kept Rashad Jennings out of the end zone on a 3rd-and-1 plunge. NaVorro Bowman, Michael Wilhoite and Ian Williams were in position to smother the Giants running back. New York tied the game on a 22-yard Josh Brown field goal. The Giants evened the score with a 9-play, 76-yard scoring drive that took 4:57 off the clock.

Giants tied the game 3-3 with 6:22 left in the first quarter

Hyde stopped for 1-yard loss on first down. On 3rd-and-7, Kaepernick tucked and ran along the left sideline for a gain of 9. On a 3rd-and-8 from San Francisco's 33, Kaepernick left the pocket and was brought down out of bounds for a 3-yard loss by defensive end Damontre Moore, who was credited with a sack. Bradley Pinion supplied a 50-yard punt. The Giants were flagged for an illegal block in the back penalty, which pushed them back to their 19-yard line.Score is tied 3-3 with 3:04 left in the first quarterSecond Quarter

Eli Harold entered the game at right outside linebacker in place of Lemonier. The Giants picked up a pair of first downs and face a 3rd-and-7 from their own 47 on the first play of the second quarter. Beckham got loose again on a deep crossing route. The second-year receiver picked up 31 yards on the catch and run. Bowman chased him down from behind for the open-field tackle. New York took the lead with a 2-yard Manning touchdown pass to running back Shane Vereen. Unlike their first drive, Beckham's big play was capitalized by the Giants. It stood as the biggest moment on a 14-play, 81-yard scoring drive that took 5:47 off the clock.
Giants lead 10-3 with 12:15 left in the second quarter
Beason (concussion) was ruled out by New York before San Francisco's third offensive possession. The 49ers made a personnel change before their third drive. Tiller has replaced Jordan Devey at right guard. Quinton Patton picked up a first down on a 2-yard reception. Hyde, however, lost seven yards on a carry to his right and the loss put San Francisco in a long third-down. Kaepernick's screen pass to tight end Garrett Celek was tackled well short of the first-down marker, forcing the 49ers to punt. Pinion connected on a 41-yard punt, which was returned by Giants wide receiver Dwaye Harris to their own 34.

Giants lead 10-3 with 8:02 left in the second quarterManning has completed three passes to Reuben Randle, two of which have gone for first downs. Kenneth Acker picked up the Giants receiver and drove him into the MetLife Stadium turf with a UFC-like takedown on the third reception, which also moved the chains. On 3rd-and-4 from New York's 23, Manning's short pass to Harris was dropped as Aaron Lynch applied pressure on the Giants quarterback and was credited with a quarterback hit. The dropped pass was a big break for the 49ers defense. Brown connected on a 41-yard field goal to give New York a 10-point advantage following their 10-play, 43-yard scoring drive that took 4:05 off the clock.

Bowman has nine tackles.

Giants lead 13-3 with 3:57 left in the second quarterTiller remained in the game. On second down from the 25, Kaepernick lofted a short pass to fullback Bruce Miller, who raced up the right sideline for a gain of 19. On the next play, Torrey Smith was held down the field by Giants cornerback Prince Amukamara. Kaepernick connected with Smith two plays later for a gain of 17 on a slant pass into New York territory. Kaepernick completed a 6-yard pass to McDonald to set up a second down at the 28-yard line when play resumes afte the 2-minute warning. Kaepernick rushed up the middle on a 3rd-and-4 from the 28, but he was stripped by Antonio Rodgers-Cromartie. However, Kaepernick recovered his own fumble to keep the 49ers drive alive at at the 14-yard line. Anquan Boldin picked up 9 yards on a quick out from Kaepernick, but was pushed out of bounds 1-yard short of the first-down marker. A third-down rollout by the 49ers signal-caller went incomplete when his pass to Boldin sailed a bit high for his intended target. Dawson came in to make a 22-yard field goal. The 49ers put together a 11-play, 76-yard scoring drive that took 2:56 off the clock.

Giants lead 13-6 with 1:01 left in the second quarter

Manning marched New York back into San Francisco territory. With three timeouts at his disposal, Manning found tight end Will Tye on a pair of big gainers, then followed it with a 18-yard pass to Harris down to the 14-yard line. Giants coach Tom Coughlin used his third timeout with 14 seconds left in the half.Tramaine Brock wrestled a Manning pass away from Beckham in the back right corner of the end zone to record the game's first turnover. The play resulted in a touchback. Kaepernick kneeled on the ball to end the half.

Giants lead 13-6 at the half

FIRST HALF ANALYSIS*

The 49ers have put together a pair of long scoring drives, but the visiting team has not found the end zone. The Giants have, and that's why they're leading the game.

Kaepernick is San Francisco's leading rusher with 23 yards on three carries. New York's top-ranked rush defense (without Kennard and Ayers) has bottled up Hyde to the tune of eight carries for 12 yards in the first half. Hyde's 7-yard loss didn't help his rushing total.

Third-down conversions will be key in the final 30 minutes of play. New York has converted 5-of-7 third downs, while San Francisco has picked up 3-of-7 third-down conversions.

Can the 49ers move the chains and get into the end zone? We'll know more when second-half play resumes.

Third Quarter

Manning picked up a chunk of yards with a 24-yard completion to Harris, but the 49ers defense eventually forced a punt from midfield. Jarryd Hayne fair caught his first punt return of the night at the 11-yard line.

Giants lead 13-6 with 12:56 left in the third quarter

Devey has re-entered the game for Tiller at right guard. The 49ers also announced Bush has re-injured his calf injury and is questionable to return. On 3rd-and-2 from the 20, Kaepernick lofted a perfect throw to Boldin, who picked up 37 yards. Former 49ers safety Craig Dahl recorded the tackle. He entered the game for Brandon Merriweather, who injured his knee early in the drive.Hyde proceeded to rush for a game-high 22 yards down to New York's 21. Hayne entered the game and converted a 3rd-and-1 in the red zone. It was easily the biggest moment of his football career.

With new life, Kaepernick finished the drive with a 3-yard touchdown pass to Boldin on third-and-goal. The 10-play, 88-yard drive took 4:56 off the clock. It also broke Kaepernick's 10-quarter streak of not throwing a touchdown pass.49ers tied the game at 13 with 8:00 left in the third quarter

The 49ers forced a three-and-out at the right time. Hayne's first punt return opportunity went for 16 yards and featured a nifty cut-back move in the open field. A holding penalty, however, put the 49ers in a 3rd-and-20 predicament and ultimately led to a 41-yard Pinion punt.Game is tied at 13 with 4:30 left in the third quarter

New York's offensive scoring draught ended with a 17-yard touchdown catch by Beckham. The 49ers were close to bringing down Manning for a key sack, but the crafty quarterback was able to get the ball out fast. Manning's throw to Beckham saw the second-year wideout quickly dash to the front left pylon to cap a 7-play, 61-yard scoring drive that took 3:16 off the clock.

Giants lead 20-13 with 1:07 left in the third quarterTiller has returned to the game for Devey. Boldin picked up 7 yards on a slant to move the chains at the end of the third quarter.Fourth Quarter Kaepernick converted another third down with a 15-yard throw to Celek. Two plays later, Kaepernick threw deep to Smith, who drew a pass interference penalty on Giants rookie safety Landon Collins. The penalty gave the 49ers the ball 1st and 10 from New York's 15-yard line.

Hyde took the first-down run down to 2-yard line with an impressive 13-yard carry around the left edge. Hyde seemed to be getting stronger as the game continued.

Kaepernick converted another, huge, mega, third-down with a 5-yard touchdown to Celek, who slipped behind Unga for an easy score. It was Celek's first career touchdown reception, too.

Kaepernick's second touchdown of the game finished off an 11-play, 80-yard scoring drive that took 4:25 off the clock.

49ers tied the game at 20 with 11:49 left in the fourth quarterBeckham suffered a hamstring injury on New York's previous drive and did not return to the field for New York's next possession. Without their star receiver, the Giants drove down the field and nearly turned the ball over in the end zone when Manning's pass was nearly intercepted by Acker.

New York took the lead with a 24-yard field goal to end a 14-play, 74-yard field goal that took 7:20 off the clock.

Giants lead 23-20 with 4:29 left in the fourth quarter

Kaepernick completed a 25-yard pass to Smith on a well-designed screen pass. On the next play, Kaepernick lofted a 26-yard pass to Boldin. Two plays later, Hyde carried the ball down to New York's 2-yard line.

On 2nd-and-goal, Rodgers-Cromartie was flagged for defensive holding on Smith. It was the third defensive penalty drawn by the 49ers wideout.

Hyde put the 49ers ahead with a 1-yard run behind the left side of the line. The running play ended a 7-play, 80-yard scoring drive that took 2:44 off the clock.

49ers lead 27-23 with 1:45 left in the fourth quarter

Manning hit Vereen for a 16-yard gain down to San Francisco's 44-yard line. The Giants called their second timeout with :47 left in the game.

Manning's next throw wobbled into the air long enough for Brock to dive forward to make an interception. The turnover was immediately challenged by the NFL replay officials. The call was overturned, which gave the ball back to New York with :45 left to play.

Beckham returned to the field and earned a defensive holding penalty. On the next play, Manning threw a 12-yard touchdown pass to tight end Larry Donnell.

Heart-breaking.

The Giants drove eight plays, to go 82 yards and took 1:24 off the clock to take the lead.

Giants lead 30-27 with :21 left in the fourth quarter

That is the final score.

Giants get the Donnell touchdown for the win.

49ers.com/live will have postgame press conferences from Jim Tomsula and others.