Game-by-game Notes for the 49ers 2019 Regular Season Schedule

The San Francisco 49ers have announced their 2019 regular season schedule as well as the dates and times of their four preseason games.

The 49ers will face the NFC South and AFC North in cross-divisional play while continuing to battle their NFC West opponents twice a year. Entering the team's fifth season at Levi's Stadium, San Francisco will host the Cleveland Browns and Pittsburgh Steelers for the first time in the venue.

The Niners open the regular season on the road by traveling to Tampa to take on the Buccaneers at Raymond James Stadium. The team is scheduled to play in three prime time games during the regular season in 2019, with two on ESPN's Monday Night Football (Week 5 vs. Cleveland & Week 10 vs. Seattle) and one on FOX/NFL Network/Amazon's Thursday Night Football (Week 9 at Arizona).

A Closer Look at the 2019 Schedule…

· The Niners open the regular season on the road in back-to-back seasons for the first time since 2009-10.

· This will be the first time since 1997 that San Francisco opens the season with consecutive road games. The season opener that year was also in Tampa.

· The 49ers open and close the regular season on the road (Week 1 at Tampa Bay and Week 17 at Seattle) for the first time since 1997, when the team finished 13-3 and won the NFC West Division.

· The 49ers face four teams in 2019 that reached the postseason in 2018 (Baltimore, Los Angeles Rams, New Orleans and Seattle).

· The Pittsburgh Steelers (Week 3) and Cleveland Browns (Week 5) will be making their first visits to Levi's Stadium.

· San Francisco has two scheduled games on ESPN's Monday Night Football for the second-consecutive season. The team will also face the Denver Broncos on MNF in the preseason on August 19.

Week 1 – Sunday, September 8 at Tampa Bay – 1:25 p.m. PT on FOX

• The 49ers are 17-7 overall vs. Tampa Bay, including a 5-4 record on the road.
• San Francisco travels to Tampa Bay for the second-consecutive season and in back-to-back seasons for the first time since 2010-11.
• The Niners have won four of the past seven meetings between the two teams.
• San Francisco opens the season at Tampa Bay for the first time since 1997. This marks the first time the 49ers visit an NFC South team in Week 1 since the division was formed in 2002.

Week 2 – Sunday, September 15 at Cincinnati – 10:00 a.m. PT on FOX

• San Francisco owns the overall series record vs. Cincinnati, 11-4, including a 4-2 record versus the Bengals on the road.
• The 49ers will travel to Cincinnati for the first time since 2011, when they defeated the Bengals, 13-8.

Week 3 – Sunday, September 22 vs. Pittsburgh – 1:25 p.m. PT on CBS

• San Francisco owns the overall series record vs. Pittsburgh 11-10, and is 5-5 at home in the series.
• This marks the first time San Francisco hosts Pittsburgh since defeating the Steelers, 20-3, in 2011.

Week 4 – Sunday, September 29 – BYE

• This marks the first time since 2002 that the 49ers have had their BYE in Week 4.
• Since the NFL re-introduced the BYE in 1990, this marks only the fifth time the 49ers have had their BYE in Week 4 or earlier (1990, 1996, 1998, 2002).

Week 5 – Monday, October 7 vs. Cleveland – 5:15 p.m. PT on ESPN

• San Francisco is 7-12 overall vs. Cleveland and 5-5 at home.
• The 49ers are hosting the Browns for the first time since defeating Cleveland 20-10 in 2011.
• The Niners own a 48-27 record on Monday Night Football.
• San Francisco hosts Cleveland on MNF for the first time in the series history.
• The two teams faced each other on a Monday in Cleveland on September 13, 1993 (L, 13-23).
• The 49ers are facing an AFC opponent in primetime for the first time since playing the Denver Broncos on the road in 2014.

Week 6 – Sunday, October 13 at Los Angeles Rams – 1:05 p.m. PT on FOX

• The 49ers have won two of three matchups at the LA Memorial Coliseum since the Rams returned to Los Angeles in 2016.
• The 49ers hold a 35-33-1 edge against the Rams on the road in the all-time series.

Week 7 – Sunday, October 20 at Washington – 10:00 a.m. PT on FOX

• The Niners lead the overall series vs. Washington, 20-11-1.
• The 49ers have won four of the last five matchups against Washington.
• San Francisco heads to FedExField for the second time in the past three seasons.

Week 8 – Sunday, October 27 vs. Carolina – 1:05 p.m. PT on FOX

• The 49ers are 8-13 in the all-time series vs. Carolina and 3-7 at home.
• San Francisco looks for their first home win against Carolina since defeating the Panthers, 24-14, on October 7, 2001.
• The 49ers are hosting the Panthers for the first time since opening the 2017 season at Levi's Stadium against Carolina, head coach Kyle Shanahan's first game with the team.

Week 9 – Thursday, October 31 at Arizona – 5:20 p.m. PT on FOX/NFLN/Amazon

• San Francisco owns the overall series record vs. Arizona, 29-26.
• This marks the first time since 2013 that San Francisco has their Thursday Night Football game on the road [W, 35-11 at StL (9/26/13)].
• The two teams square off on Thursday Night Football for the second time in three years, with San Francisco hosting Arizona on TNF in 2016.

Week 10 – Monday, November 11 vs. Seattle – 5:15 p.m. PT on ESPN

• San Francisco is 16-25 in the all-time series vs. Seattle and 9-10 at home.
• The Niners have won six out of the last 10 home games against the Seahawks, including a 26-23 overtime victory over Seattle at Levi's Stadium in 2018.
• San Francisco faces Seattle on Monday Night Football for the fourth time in the history between the two franchises.
• The two teams play in primetime for the first time since 2015.

Week 11 – Sunday, November 17 – vs. Arizona – 1:05 p.m. PT on FOX

• The 49ers are 17-12 at home vs. the Cardinals and have won six out of their last 10 home games vs. Arizona.
• Since divisional realignment in 2002, this marks the first time the 49ers and Cardinals will meet two times in three weeks.

Week 12 – Sunday, November 24 vs. Green Bay – 1:25 p.m. PT on FOX

• The 49ers have won four out of the last six overall games against the Packers.
• San Francisco is 30-36-1 in the all-time series vs. Green Bay and 18-12-1 at home.
• The Niners and Packers squared off in 2018 on ESPN's Monday Night Football, and take on Green Bay in consecutive regular seasons for the first time since 2012-13.

Week 13 – Sunday, December 1 at Baltimore – 10:00 a.m. PT on FOX

• The 49ers are 2-4 overall vs. Baltimore.
• San Francisco is looking for their first road win against the Ravens, as the team travels to Baltimore for the first time since a 2011 matchup on Thanksgiving night.
• The 49ers look for their first win in the city of Baltimore since defeating the Baltimore Colts, 24-21, in 1969.

Week 14 – Sunday, December 8 at New Orleans – 10:00 a.m. PT on FOX

• San Francisco is 48-26-2 all-time vs. New Orleans and 25-14 on the road.
• The 49ers travel to New Orleans for the first time since their 27-24 overtime victory over the Saints in 2014.
• The Niners have won two of the past three meetings against the Saints at the Mercedes-Benz Superdome.

Week 15 – Sunday, December 15 vs. Atlanta – 1:25 p.m. PT on FOX

• San Francisco owns the overall series record vs. Atlanta, 47-31-1, and is 28-11 at home.
• The 49ers look to go 2-0 against the Falcons at Levi's Stadium, as San Francisco defeated Atlanta, 17-16, in their last home matchup in 2015.

Week 16 – Saturday or Sunday, December 21 or 22 vs. Los Angeles Rams

• The dates and start times for Week 16 will be announced no later than following Week 8 contests.
• San Francisco leads the all-time series against the Rams, 69-67-3.
• San Francisco is 6-3-1 in their last 10 meetings at home against the Rams.
• The overall home series against the Rams is tied at 34-34-2.

Week 17 – Sunday, December 29 at Seattle – 1:25 p.m. PT on FOX

• The 49ers are 7-15 overall on the road at Seattle.
• San Francisco is looking to win at Seattle for the first time since 2011.
• The Niners finish the regular season in Seattle for the first time since the 1997 season.