The San Francisco 49ers return home to face Aaron Rodgers and the unbeaten Green Bay Packers at Levi's® Stadium.
San Francisco has won each of the last four meetings, including two in the postseason. All of those victories have come since 2012.
The Packers are traveling across the country on a short week after defeating the Kansas City Chiefs on Monday night. The 49ers have lost two consecutive games, but they won their home opener in Week 1 versus the Minnesota Vikings.
Here are the experts' picks from around the web for the Week 4 clash. Give us your predictions in the comment section below...
Pete Prisco of CBS Sports: Packers 34, 49ers 16
"The Packers are the best team in the league and have the best quarterback. The 49ers are struggling in large part because their quarterback is struggling. Colin Kaepernick has to be better. The Packers play on a short turnaround, so that could factor."
Pete Schrager of Fox Sports: 49ers 31, Packers 28
Check out photos from the 49ers previous meetings against the Green Bay Packers.
Roland Lakes sacks Bart Starr in the Packers 13-0 win in Nov. 1967.
John Brodie escapes Jim Weatherwax in Nov. 1967.
Charles Haley sacks Don Majkowski in Nov. 1989.
Ronnie Lott tackles Brent Fullwood in Nov. 1989.
Mike Cofer attempts a field goal.
Joe Montana talks with Tim Harris during the Packers 21-17 win in Nov. 1989.
Joe Montana throws a pass during the Packers 21-17 win in Nov. 1989.
Ronnie Lott runs back a fumble.
Doug Evans (left) breaks up a pass intended for John Taylor during the Packers 27-17 win in the 1995 NFC Divisional playoffs.
Merton Hanks during the Packers 27-17 win in the 1995 NFC Divisional playoffs.
Jerry Rice breaks away from Wayne Simmons during the Packers 27-17 win in the 1995 NFC Divisional playoffs.
J.J. Stokes during the Packers 27-17 win in the 1995 NFC Divisional playoffs.
Brent Jones during the Packers 27-17 win in the 1995 NFC Divisional playoffs.
Steve Young during the Packers 27-17 win in the 1995 NFC Divisional playoffs.
Steve Young and Jim McMahon during the 1995 NFC Divisional playoff game.
Lee Woodall and Mark Chmura tussle during the Packers 35-14 win in the 1996 NFC Divisional playoffs.
Brett Favre and Tim McDonald embrace after the Packers 35-14 win in the 1996 NFC Divisional playoffs.
Antonio Freeman and Tyronne Drakeford battle during the Packers 23-10 win in the 1997 NFC Championship Game.
Steve Young during the Packers 23-10 win in the 1997 NFC Championship Game.
Steve Young in the Packers' 23-10 win in the 1997 NFC Championship Game.
Terrell Owens during the 49ers 30-27 win in the 1998 NFC Championship Wild Card game.
Kevan Barlow during in Dec. 2002.
Jeff Garcia during the Packers 20-14 win in Dec. 2002.
Terrell Owens during the Packers 20-14 win in Dec. 2002.
Andre Carter rushes Brett Favre in Nov. 2003.
Terrell Owens in Nov. 2003.
Alex Smith completes a pass in Dec. 2006.
Delanie Walker during the Packers 30-19 win in Dec. 2006.
Frank Gore breaks tackles in Dec. 2006.
Vernon Davis during the Packers 30-19 win in Dec. 2006.
James Jones and Tarell Brown at Lambeau Field in Nov. 2009.
Michael Crabtree gets a first down in Nov. 2009.
Justin Smith rushes Aaron Rodgers in Nov. 2009.
Patrick Willis during the Packers 30-24 win in Nov. 2009.
Vernon Davis during the Packers 34-16 win in Dec. 2010.
Frank Gore during the 49ers 30-22 win in Sept. 2012.
Alex Smith and Aaron Rogers talk after the 49ers 30-22 win in Sept. 2012.
Michael Crabtree during the 49ers 45-31 win in the 2012 NFC Divisional playoffs.
Mike Iupati during the 49ers 45-31 win in the 2012 NFC Divisional playoffs.
Colin Kaepernick during the 49ers 45-31 win in the 2012 NFC Divisional playoffs.
Patrick Willis during the 49ers 45-31 win in the 2012 NFC Divisional playoffs.
Colin Kaepernick during the 49ers 45-31 win in the 2012 NFC Divisional playoffs.
Vernon Davis during the 49ers 45-31 win in the 2012 NFC Divisional playoffs.
Anquan Boldin during the 49ers 34-28 win in the 2013 regular season opener.
Anquan Boldin during the 49ers 34-28 win in the 2013 regular season opener.
Alex Boone during the 49ers 34-28 win in the 2013 regular season opener.
Anthony Davis during the 49ers 34-28 win in the 2013 regular season opener.
NaVorro Bowman during the 49ers 34-28 win in the 2013 regular season opener.
Tarell Brown recovers a fumble during the 49ers 34-28 win in the 2013 regular season opener.
Mike Iupati and Colin Kaepernick during the 49ers 34-28 win in the 2013 regular season opener.
Eric Reid during the 49ers 34-28 win in the 2013 regular season opener.
Jonathan Goodwin during the 49ers 34-28 win in the 2013 regular season opener.
Patrick Willis during the 49ers 34-28 win in the 2013 regular season opener.
Vernon Davis during the 49ers 34-28 win in the 2013 regular season opener.
Anquan Boldin during the 2013 NFC Divisional Round victory.
Colin Kaepernick during the 2013 NFC Divisional Round victory.
Perrish Cox runs the ball during the 49ers 2013 regular season opener.
NaVorro Bowman lines up during in Sept. 2013.
Tramaine Brock during the 2013 NFC Divisional Round victory.
Michael Crabtree during the 2013 NFC Divisional Round victory.
Vernon Davis scores against the Packers defense in Oct. 2015.
Vernon Davis during the 2013 NFC Divisional Round victory in 2013.
Frank Gore during the 2013 NFC Divisional Round victory.
Colin Kaepernick during the 2013 NFC Divisional Round victory.
Colin Kaepernick during the 2013 NFC Divisional Round victory.
Justin Smith during during the 2013 NFC Divisional Round victory.
"The media pile-on of Colin Kaepernick has hit its apex. You'd think he'd never completed a pass before the way people have been writing and talking about him this week. I'd say to be patient before burying Kaepernick and these 49ers. Bad losses happen. It's how you respond that matters. I've seen Kaepernick destroy Dom Capers' Packers defenses enough to know anything's possible. This is your upset special."
Elliot Harrison of NFL.com: Packers 34, 49ers 13
"This matchup has provided so many beauties through the years. Personal favorite: in the Divisional Round of the 1995 playoffs, when Green Bay walked into Candlestick an underdog and was up 21-0 before you could blink."
Mike Florio of Pro Football Talk: Packers 38, 49ers 23
"The 49ers beat the Packers twice in 2012 and twice in 2013. The Packers haven't forgotten that."
ESPN's panel of 13 experts: 13 pick Packers, zero pick 49ers
USA TODAY's panel of seven experts: seven pick Packers, zero pick 49ers
