With San Francisco's first pick in the 2022 NFL Draft, the 49ers selected defensive lineman Drake Jackson from the University of Southern California.
As a Trojan, Jackson appeared in 28 games, with 26 starts, and recorded 103 tackles, including 25 for losses, 12.5 sacks, 4 deflections, 2 interceptions, 1 fumble recovery and 1 forced fumble.
Jackson was a quarterfinalist for the 2021 Lott IMPACT Trophy and made the All-Pac-12 second team, AP All-Pac-12 second team, Pro Football Focus All-Pac-12 second team and Phil Steele All-Pac-12 second team.