Samuel Sr. Breaks Loose for a 76-Yard Score

San Francisco 49ers RB Isaac Guerendo sped past the Buffalo Bills defense for a touchdown on "SNF".

San Francisco 49ers WR Deebo Samuel Sr. has room to roam on a 60-yard kick return in the team's Week 13 matchup against the Buffalo Bills.

San Francisco 49ers RB Jordan Mason zipped through Bills defenders for a 27-yard run in the team's Week 13 matchup against the Buffalo Bills.

San Francisco 49ers RB Christian McCaffrey powers through for a 19-yard run against the team's Week 13 matchup against the Buffalo Bills.

Check out the top 10 catches from San Francisco 49ers tight end George Kittle from his eight year career, so far.

Watch the San Francisco 49ers top highlights from TE George Kittle, WR Deebo Samuel Sr., DL Leonard Floyd and more vs. the Green Bay Packers in Week 12.

San Francisco 49ers' linebacker Leonard Floyd bags his second sack of Green Bay Packers' quarterback Jordan Love, and while he doesn't force a turnover he does the Packers to punt.

San Francisco 49ers TE George Kittle makes a back-hip catch to advance the 49ers into Green Bay Packers territory.

San Francisco 49ers DL Leonard Floyd sacked the Green Bay Packers QB Jordan Love.

San Francisco 49ers RB Jordan Mason takes the football for a 16-yard gain in the team's Week 12 matchup against the Packers.

San Francisco 49ers WR Deebo Samuel caught a trick-play pass from QB Brandon Allen in the team's Week 12 matchup against the Green Bay Packers.

San Francisco 49ers QB Brandon Allen connected with TE George Kittle in the end zone in the team's Week 12 matchup against the Green Bay Packers.

Watch the San Francisco 49ers top highlights vs. the Seattle Seahawks in the Week 11 contest.

Check out the best plays from San Francisco 49ers linebacker Fred Warner during the first 11 weeks of the 2024 NFL season.

San Francisco 49ers QB Brock Purdy connected with WR Jauan Jennings for a touchdown against the Seattle Seahawks.

San Francisco 49ers DL Nick Bosa got to Seattle Seahawks QB Geno Smith for his second sack of the game.

San Francisco 49ers CB Isaac Yiadom intercepted Seattle Seahawks QB Geno Smith's pass in the team's Week 11 matchup.

San Francisco 49ers DL Yetur Gross-Matos tracked down Seahawks quarterback Geno Smith for his first sack as a member of the San Francisco 49ers.

San Francisco 49ers QB Brock Purdy sprinted past Seahawks defenders for a first down in the team's Week 11 matchup.

San Francisco 49ers QB Brock Purdy sprinted to the end zone for a touchdown in the team's Week 11 matchup against the Seahawks.

Check out the best plays from San Francisco 49ers defensive back Deommodore Lenoir's first four seasons in the NFL.

Watch San Francisco 49ers quarterback Brock Purdy's Week 10 highlights as he passed for 353 yards in a 23-20 win over the Tampa Bay Buccaneers.

Check out the best plays from San Francisco 49ers running back Christian McCaffrey's 2024 regular season debut.

Watch the San Francisco 49ers top highlights vs. the Tampa Bay Buccaneers in the Week 10 contest.

San Francisco 49ers QB Brock Purdy connected with RB Christian McCaffrey in the team's Week 10 matchup.