Antone Exum Jr. Opens the Game with a Pick-six

Check out the best plays from San Francisco 49ers defensive back Deommodore Lenoir's first four seasons in the NFL.

Watch San Francisco 49ers quarterback Brock Purdy's Week 10 highlights as he passed for 353 yards in a 23-20 win over the Tampa Bay Buccaneers.

Check out the best plays from San Francisco 49ers running back Christian McCaffrey's 2024 regular season debut.

Watch the San Francisco 49ers top highlights vs. the Tampa Bay Buccaneers in the Week 10 contest.

San Francisco 49ers QB Brock Purdy connected with RB Christian McCaffrey in the team's Week 10 matchup.

San Francisco 49ers DL Nick Bosa took down Tampa Bay Buccaneers quarterback during the team's Week 10 matchup.

San Francisco 49ers QB Brock Purdy zipped a touchdown dime to TE George Kittle in the corner of the end zone in the team's Week 10 matchup against the Buccaneers.

San Francisco 49ers TE George Kittle cut through Buccaneers coverage in the team's Week 10 matchup.

San Francisco 49ers WR Jauan Jennings maneuvered past Buccaneers defenders in the team's Week 10 matchup.

San Francisco 49ers TE George Kittle secured QB Brock Purdy's pass in the team's Week 10 matchup against the Tampa Bay Buccaneers.

San Francisco 49ers WR Ricky Pearsall found the end zone for his first NFL touchdown against the Tampa Bay Buccaneers.

Check out the San Francisco 49ers top plays from each week of the first half of the 2024 NFL regular season.

Watch every San Francisco 49ers touchdown from the first half of the 2024 NFL regular season.

Relive highlight-reel plays from San Francisco 49ers quarterback Brock Purdy during the first eight weeks of the 2024 NFL season.

Watch all of San Francisco 49ers rookie running back Isaac Guerendo's best plays from his 102-yard game against the Dallas Cowboys in Week 8 of the 2024 NFL regular season.

Watch every catch from San Francisco 49ers tight end George Kittle from his 128-yard game against the Dallas Cowboys in Week 8 of the 2024 NFL regular season.

Watch the San Francisco 49ers top highlights vs. the Dallas Cowboys in the Week 8 contest.

San Francisco 49ers WR Ricky Pearsall raced down the sideline for a 39-yard gain against the Dallas Cowboys.

San Francisco 49ers QB Brock Purdy pushed the pile into the end zone for a touchdown in the team's Week 8 matchup against the Dallas Cowboys.

San Francisco 49ers TE George Kittle connected with QB Brock Purdy in the end zone.

San Francisco 49ers DB Deommodore Lenoir snatched a pass from Dallas Cowboys QB Dak Prescott for an interception in the team's Week 8 matchup.

San Francisco 49ers RB Isaac Guerendo's raced into the end zone against the Dallas Cowboys for his first NFL touchdown.

San Francisco 49ers TE George Kittle slipped to his right for a 30-yard catch and run on 'SNF' against the Dallas Cowboys

San Francisco 49ers S Malik Mustapha broke up a potential touchdown pass to Dallas Cowboys TE Brevyn Spann-Ford in the back of the end zone.

San Francisco 49ers RB Isaac Guerendo had room to roam on 19-yard catch and run against the Dallas Cowboys.