Buffalo Bills at San Francisco 49ers on December 7, 2020

History: 49ers vs. Bills

• San Francisco is 6-6 vs. Buffalo, including a 4-3 record at home. The Niners have won three of the past five meetings.
• The 49ers are facing the Bills on Monday Night Football for the first time, as San Francisco holds a 49-28 overall record on MNF. The Niners 49 victories on MNF are the most by any NFL franchise.
• The Bills are making their first trip to Levi's® Stadium, with San Francisco hosting Buffalo for the first time since October 7, 2012, when they defeated the Bills, 45-3.

Players and Coaches to Know:

49ers

• Head Coach: Kyle Shanahan
• Quarterback: Jimmy Garoppolo
• Wide Receiver: Deebo Samuel
• Cornerback: Richard Sherman 

Bills

• Head Coach: Sean McDermott
• Quarterback: Josh Allen
• Wide Receiver: Stefon Diggs
• Cornerback: Tre'Davious White