San Francisco 49ers at Arizona Cardinals

History: 49ers at Cardinals

• San Francisco owns the overall series record vs. Arizona, 31-26.
• Last season, the two teams squared off on Thursday Night Football for the second time in four years, with San Francisco defeating Arizona on the road, 28-25.
• In 2019, the 49ers defeated the Los Angeles Rams at home on Saturday Night Football, 34-31.

Players and Coaches to Know:

49ers

• Head Coach: Kyle Shanahan
• Quarterback: Jimmy Garoppolo
• Running Back: Raheem Mostert
• Cornerback: Richard Sherman 

Cardinals

• Head Coach: Kliff Kingsbury
• Quarterback: Kyler Murray
• Running Back: Kenyan Drake
• Cornerback: Patrick Peterson