San Francisco 49ers 2022 Opponents

Last meeting at home: November 7, 2021

Score: Cardinals 31 - 49ers 17

49ers lead all-time series 32-29-0

Last meeting at home: November 15, 2021

Score: 49ers 31 - Rams 10

49ers lead all-time series 75-68-3

Last meeting at home: October 3, 2021

Score: Seahawks 28 - 49ers 21

Seahawks lead all-time series 30-17-0

Last meeting at home: November 6, 2016

Score: Saints 41 - 49ers 23

49ers lead all-time series 49-27-2

Last meeting at home: October 23, 2016

Score: Buccaneers 34 - 49ers 17

49ers lead all-time series 18-7-0

Last meeting at home: October 5, 2014

Score: 49ers 22 - Chiefs 17

All-time series tied 7-7-0

Last meeting at home: December 20, 2014

Score: Chargers 38 - 49ers 35

Chargers lead all-time series 8-7-0

Last meeting at home: October 11, 2020

Score: Dolphins 43 - 49ers 17

Dolphins lead all-time series 8-6-0

Last meeting at home: December 13, 2020

Score: Commanders 23 - 49ers 15

49ers lead all-time series 21-12-1

Last meeting in Arizona: October 10, 2021

Score: Cardinals 17 - 49ers 10

49ers lead all-time series 32-29-0

Last meeting in Los Angeles: January 30, 2022

Score: Rams 20 - 49ers 17

49ers lead all-time series 75-68-3

Last meeting in Seattle: December 5, 2021

Score: Seahawks 30 - 49ers 23

Seahawks lead all-time series 30-17-0

Last meeting in Atlanta: December 18, 2016

Score: Falcons 41 - 49ers 13

49ers lead all-time series 48-32-1

Last meeting in Carolina: September 18, 2016

Score: Panthers 46 - 49ers 27

Panthers lead all-time series 13-9-0

Last meeting in Denver: October 19, 2014

Score: Broncos 42 - 49ers 17

49ers lead all-time series 8-7-0

Last meeting in Oakland: December 7, 2014

Score: Raiders 24 - 49ers 13

All-time series tied 7-7-0

Last meeting in Chicago: October 31, 2021

Score: 49ers 33 - Bears 22

49ers lead all-time series 35-32-1