SEATTLE – The San Francisco 49ers were defeated for the second time this season on Sunday in a 37-18 road loss to the Seattle Seahawks.

Seattle jumped out to an early 14-0 lead and never looked back. The 49ers are now 1-2 on the season and will come home in Week 4 to host the Dallas Cowboys. Seattle improved to 2-1 and now sits atop the NFC West.

Here are the top takeaways from San Francisco's Week 3 defeat.

Seahawks Running Game Sets Tone Early

Last season it was Thomas Rawls who racked up 209 rushing yards against the 49ers. On Sunday, it was Christine Michael who posted big numbers.

Michael's first carry of the game went for a 41-yard touchdown to put the Seahawks up 7-0 on just the third play from scrimmage. The ball-carrier's first five carries went for 71 yards. Michael added his second score of the day, a 3-yard run, on Seattle's very next possession.

San Francisco kept the running back in check from there for the most part, but the damage had already been done. Michael finished the game with 106 yards on 20 carries and two touchdowns.

After bottling up Todd Gurley in Week 1, San Francisco has now allowed 100-yard rushers in each of the past two games (Carolina Panthers running back Fozzy Whittaker posted 16-100 in Week 2).

Seattle Wins Third-down Battle

Seattle converted 5-of-6 third-down attempts to open the game and scored touchdowns on three out of its first four possessions. Doug Baldwin made an incredible, one-handed catch to gain 12 yards on one third down. Baldwin caught another third-down pass deep down the middle of the field for a 59-yard gain. Jimmy Graham caught third-down passes of 18 yards and 40 yards. On the latter, the tight end came down with a jump ball, taking it away from Eric Reid.

Both Baldwin and Graham topped 100 yards receiving in the first half. Baldwin finished the game with eight catches for 164 yards and one touchdown. Graham totaled 100 yards on six receptions and one touchdown.

Seattle finished the game 9-of-14 on third down. Conversely, San Francisco converted just 4-of-15 third-down attempts.

Pierre Garçon Gets Going Late

San Francisco's starting running back broke off a 34-yard run in the fourth quarter, but it was already much too late with the 49ers trailing 37-3. Hyde capped the drive with the 49ers first touchdown of the day, an 8-yard run to make it 37-10. The ball-carrier added a second score, another 8-yard run, and a two-point conversion with 1:01 remaining in the contest.

Hyde finished the game with 21 carries for 103 yards and the two scores in what was an overall slow day for San Francisco's offense.

Blaine Gabbert completed 14-of-25 pass attempts for 119 yards, no touchdowns and one interception. Torrey Smith led the 49ers with three receptions for 35 yards.

Niner Nuggets

-- Nick Bellore grabbed his first-career interception, a fourth-quarter pick of Seahawks backup quarterback Trevone Boykin

-- Jeremy Kerley recorded a 20-yard punt return in the first quarter, his longest of the season.

-- Jimmie Ward left the game in the second quarter with a right leg injury. The cornerback was covering a kickoff and went down without being touched.

-- Garrett Celek left the game in the first half and was ruled out with a hip injury.

-- Torrey Smith hobbled off after an 11-yard reception in the fourth quarter with an apparent ankle injury. The wideout returned to action after missing just three plays.

-- San Francisco went scoreless in the third quarter for the third consecutive game.