It's gameday as Week 10 of the NFL season is upon us as the San Francisco 49ers are set to host Eli Manning and the New York Giants. You know the drill. Keep it here throughout the game for news, notes and highlights as the 49ers try to get their first win of the season.

PREGAME

San Francisco's offense will get a huge lift with the return of Joe Staley. The 49ers allowed 16 quarterback hits and five sacks in Week 9 against the Arizona Cardinals. Improving in pass protection will be vital for the 49ers on Sunday.

K'Waun Williams is also back in the lineup after missing two games with a quad injury. He'll likely reassume his role as the 49ers starting nickel corner.

Here are the 49ers inactives: Solomon Thomas, Elijah Lee, Aaron Lynch, George Kittle, Trent Taylor, Darrell Williams Jr., and Pita Taumoepenu.

And for the Giants: B.J. Goodson, Devon Kennard, Keenan Robinson, Davis Webb, Travis Rudolph, Donte Deayon and Chad Wheeler.

Back at home for Week 10. #NYGvsSF pic.twitter.com/GSwn6zrjRb — San Francisco 49ers (@49ers) November 12, 2017

FIRST QUARTER ("--" denotes a new possession)

The 49ers got the ball first to open the game and were gifted great field position at their own 40-yard line after the Giants sent the opening kickoff out of bounds. Pierre Garçon took his first carry down the right sideline for a gain of 28 yards. On the play, Hyde initially took the handoff to the left before bouncing it back to the right. A late hit out of bounds tacked on 15 more yards to the end of the play.

San Francisco went backwards from there. A false start penalty cost the 49ers five yards, and then Matt Breida lost six yards on a backwards pass to the left.

Robbie Gould's 43-yard field goal gave the 49ers an early 3-0 lead. (12:40)

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Eli Manning completed his first two passes, one for seven yards to Sterlling Shepard and a 15-yarder to Tavarres King. King then took an end around up the right sideline for an 11-yard gain into 49ers territory.

Manning took a shot to the end zone for Engram but couldn't connect. That brought on New York's field-goal unit.

Aldrick Rosas drilled the 47-yarder to tie the game, 3-3. (7:23)

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C.J. Beathard completed a clutch third-down pass to Kendrick Bourne for a gain of 14 yards and a first down. Marquise Goodwin followed with an end around up the right sideline that went for 18 yards to the Giants 45-yard line.

Three plays later, the 49ers went for it on 4th-and-1, but Kyle Juszczyk got stuffed short of the line to gain for a turnover on downs.

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Manning's 15-yard completion to Shepart was followed by a 20-yard run from Orleans Darkwa. San Francisco held from there as Ronald Blair III blew up a would-be screen pass and Reuben Foster tackled Shane Vereen for a short gain on third down.

Rosas made another field goal, this time from 42 yards out to make it 6-3, Giants. (1:07)

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Beathard gained seven yards on a read option to move the chains. The rookie continues to show his ability to be a weapon as a runner.

SECOND QUARTER

Beathard found Hyde for a 6-yard gain on 3rd-and-5 for another 49ers first down. A 7-yard run by Breida and a 4-yard pass to Garrett Celek moved the ball to New York's 42-yard line. Beathard then found Aldrick Robinson over the middle for a 12-yard gain. Robinson did well to make the contested catch with a defender draped all over him.

An offensive holding penalty was followed by a fumble by Juszczyk which was recovered by New York. That's Juszczyk's second lost fumble in as many weeks.

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Manning immediately connected with Shepard for a gain of 26 yards. Blair came up with the 49ers biggest play of the day, beating the right tackle around the edge and getting a sack/fumble against Manning. Eric Reid picked up the loose ball for the much-needed takeaway.

That was Blair's first sack of 2017.

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A penalty wiped out a big run by Breida, but it wouldn't matter.

On 3rd-and-8 from the 49ers 17-yard line, Beathard found Goodwin deep down the middle of the field for an 83-yard touchdown to make it 10-6, 49ers. (7:59)

Goodwin was wide open downfield, and Beathard dropped a beauty of a throw over his receiver's shoulder. On the play, Hyde had a huge blitz pickup to make the touchdown possible.

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Manning found Shepard again on third down for a 24-yard gain into 49ers territory. Darkwa then converted on 3rd-and-1 to San Francisco's 32-yard line. Roger Lewis Jr. then hauled in a 10-yard pass to get New York into the red zone.

Two plays later, Evan Engram caught a 9-yard touchdown pass from Manning to put the Giants back on top, 13-10. (2:08)

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Beathard completed a screen to Juszczyk for an 8-yard gain. On the other side of the two-minute warning, Hyde took a quick toss to the left for a gain of 10 yards. The toss went forward to officially it was a 10-yard reception. On 3rd-and-8, Beathard found Celek for a 9-yard gain to New York's 47-yard line.

On the very next play, Beathard found Celek downfield for a 47-yard touchdown to put the 49ers back on top, 17-13. (0:28)

Celek made a man miss in the middle of the field, picked up a great block from Goodwin and took it to the house. It was the longest catch of Celek's career. The score also gave Beathard his first-career multi-touchdown game.

THIRD QUARTER

Darkwa gained 10 yards on a quick pass to the left as the Giants got the ball first to open the second half. Wayne Gallman then ripped off 13 yards on a carry up the middle. Shepard made a ridiculous one-handed catch down the left sideline for an 18-yard gain. The 49ers challenged the catch, but the ruling was confirmed upon review.

Shepard has now caught all five of his targets for 90 yards.

San Francisco held from there and forced a field-goal attempt.

Rosas was no good from 34 yards out. San Francisco got the ball back at it's own 24-yard line.

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Beathard continued to roll, finding newly-signed Louis Murphy for a 40-yard catch-and-run. Hyde followed with a 21-yard run to the Giants 12-yard line. However, an offensive holding penalty was followed by a Giants interception. Beathard tried to find Hyde on a screen pass, but Olivier Vernon made an athletic play to pick off the short pass. Beathard didn't put enough air on the football and wasn't able to get it over Vernon's head.

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Darkwa immediately ripped off an 18-yard run. Elvis Dumervil sacked Manning for a loss of six yards. His 4.5 sacks are the most of any 49ers defender. Adrian Colbert blew up King down the left sideline to force an incompletion and bring on the Giants punt team.

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Victor Bolden Jr. returned the ensuing punt 17 yards to the 49ers 38-yard line. It was initially ruled that Bolden fumbled the ball, which was recovered by the Giants. Upon review, Bolden's knee was down and the 49ers kept possession.

Beathard got hit on first down. Had protection held up, he had Goodwin open downfield crossing from right to left. On 3rd-and-12, Beathard found Bourne for a 20-yard gain. Juszczyk's 12-yard reception moved the sticks again to the Giants 31-yard line. Bourne converted another third down with an 8-yard reception to the Giants19-yard line.

FOURTH QUARTER

San Francisco opened the final quarter facing 3rd-and-2 from the Giants 11-yard line.

Beathard kept the ball himself and ran it in for an 11-yard touchdown to put the 49ers up 24-13. (14:53)

That's Beathard's third-career touchdown run. The rookie looked to hurt his hand on the play and was attended to on the sideline by the 49ers medical staff.

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New York went three-and-out. Beathard took snaps on the sideline with the medical staff looking on and appeared to be cleared.

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The 49ers took over at their own 38-yard line. Beathard converted another third down with an 8-yard pass to Murphy. Then Breida ripped off a 12-yard run.

Breida hit a home run on the very next play, breaking loose for a 33-yard touchdown run to extend the 49ers lead to 31-13. (9:19)

San Francisco now has 468 yards of total offense.

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The 49ers forced another three-and-out. Manning missed an open Engram on first down. Reuben Foster made a tackle for loss on second down and has a game-high nine tackles.

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San Francisco went three and out and punted for the first time all day.

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Ronald Blair sacked Eli Manning for the second time in the game. Manning moved the ball slowly down the field with short completions with less than 2:00 remaining in the game. He then found Shepard for a 21-yard gain to the 14-yard line.

Manning connected with Lewis for a 14-yard touchdown. Darkwa's two-point conversion made it 31-21, 49ers. (1:02)

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The 49ers recovered the onside kick, took two knees and sealed their first win of 2017.