See the cleat designs highlighting causes close to their hearts in this year's "My Cause My Cleats," presented by Shoe Palace.

QB Jimmy Garoppolo
Good Tidings

QB Jimmy Garoppolo
Good Tidings

QB Jimmy Garoppolo
Good Tidings

QB Jimmy Garoppolo
Good Tidings

TE George Kittle
TAPS

TE George Kittle
TAPS

TE George Kittle
TAPS

TE George Kittle
TAPS

LB Fred Warner
Born this Way Foundation

LB Fred Warner
Born this Way Foundation

LB Fred Warner
Born this Way Foundation

Head Coach Kyle Shanahan
Institute for Myeloma and Bone Cancer Research

Head Coach Kyle Shanahan
Institute for Myeloma and Bone Cancer Research

Head Coach Kyle Shanahan
Institute for Myeloma and Bone Cancer Research

CB Emmanuel Moseley
UCSF

CB Emmanuel Moseley
UCSF

CB Emmanuel Moseley
UCSF

CB Emmanuel Moseley
UCSF

T Trent Williams
Sarcoma Foundation of America

T Trent Williams
Sarcoma Foundation of America

T Trent Williams
Sarcoma Foundation of America

General Manager John Lynch
John Lynch Foundation

General Manager John Lynch
John Lynch Foundation

General Manager John Lynch
John Lynch Foundation

P Mitch Wishnowsky
Hope for Paws

P Mitch Wishnowsky
Hope for Paws

P Mitch Wishnowsky
Hope for Paws

WR Trent Sherfield
Sarcoma Foundation of America

WR Trent Sherfield
Sarcoma Foundation of America

WR Trent Sherfield
Sarcoma Foundation of America

WR River Cracraft
Hilinski's Hope Foundation

WR River Cracraft
Hilinski's Hope Foundation

WR River Cracraft
Hilinski's Hope Foundation

WR Mohamed Sanu Sr.
Camp Okizu

WR Mohamed Sanu Sr.
Camp Okizu

WR Mohamed Sanu Sr.
Camp Okizu

TE Ross Dwelley
Autism Tree Project Foundation

TE Ross Dwelley
Autism Tree Project Foundation

TE Ross Dwelley
Autism Tree Project Foundation

TE Charlie Woerner
The Nazarene Fund

TE Charlie Woerner
The Nazarene Fund

TE Charlie Woerner
The Nazarene Fund

T Mike McGlinchey
Donor Network West

T Mike McGlinchey
Donor Network West

T Mike McGlinchey
Donor Network West

OL Laken Tomlinson
NAMI

OL Laken Tomlinson
NAMI

OL Laken Tomlinson
NAMI

OL Jake Brendel
Living For Zachary

OL Jake Brendel
Living For Zachary

OL Jake Brendel
Living For Zachary

OL Daniel Brunskill
TR 4 Heart and Soul

OL Daniel Brunskill
TR 4 Heart and Soul

OL Daniel Brunskill
TR 4 Heart and Soul

LS Taybor Pepper
Gamers Outreach Foundation

LS Taybor Pepper
Gamers Outreach Foundation

LS Taybor Pepper
Gamers Outreach Foundation

LB Demetrius Flannigan-Fowles
IAmYou360

LB Demetrius Flannigan-Fowles
IAmYou360

LB Demetrius Flannigan-Fowles
IAmYou360

LB Azeez Al-Shaair
Alzheimer's Association

LB Azeez Al-Shaair
Alzheimer's Association

LB Azeez Al-Shaair
Alzheimer's Association

FB Kyle Juszczyk
The Prostate Cancer Foundation

FB Kyle Juszczyk
The Prostate Cancer Foundation

FB Kyle Juszczyk
The Prostate Cancer Foundation

DL Samson Ebukam
T&S Foundation

DL Samson Ebukam
T&S Foundation

DL Samson Ebukam
T&S Foundation

DL Maurice Hurst
Colon Cancer Coalition

DL Maurice Hurst
Colon Cancer Coalition

DL Maurice Hurst
Colon Cancer Coalition

DL Kentavius Street
Until Freedom

DL Kentavius Street
Until Freedom

DL Kentavius Street
Until Freedom

DL Darrion Daniels
Lupus Foundation of NorCal

DL Darrion Daniels
Lupus Foundation of NorCal

DL Darrion Daniels
Lupus Foundation of NorCal

DL Arik Armstead
Armstead Academic Project

DL Arik Armstead
Armstead Academic Project

DL Arik Armstead
Armstead Academic Project

DL Arik Armstead
Armstead Academic Project

DL Alex Barrett
A Walk on Water

DL Alex Barrett
A Walk on Water

DL Alex Barrett
A Walk on Water

CB Josh Norman
STARZ24

CB Josh Norman
STARZ24

CB Josh Norman
STARZ24

CB Ambry Thomas
TUFF

CB Ambry Thomas
TUFF

CB Ambry Thomas
TUFF

C Alex Mack Eat.Learn.Play Foundation

C Alex Mack
Eat.Learn.Play Foundation

C Alex Mack
Eat.Learn.Play Foundation

S Tavon Wilson The Trigger Project

S Tavon Wilson
The Trigger Project

S Tavon Wilson
The Trigger Project

OL Jaylon Moore
American Cancer Society

OL Jaylon Moore
American Cancer Society

OL Jaylon Moore
American Cancer Society

CB Dontae Johnson
Lucile Packard Children's Hospital

CB Dontae Johnson
Lucile Packard Children's Hospital

CB Dontae Johnson
Lucile Packard Children's Hospital
In his My Cause My Cleats debut, Shanahan will wear customized sneakers representing the Institute for Myeloma and Bone Cancer Research in support of 49ers linebackers coach Johnny Holland.
Holland was diagnosed with multiple myeloma in September 2019 and has undergone several rounds of remission and relapse. Holland released a statement in August announcing his lengthy battle with cancer and his plans to step away from football to focus on his recovery.
"Unfortunately, the cancer has returned and, beginning on September 6th, I will take some time away from the team to receive treatment," said Holland. "In sharing the details of my diagnosis, my desire is that I can be an advocate and beacon of hope for those who are battling cancer to help remind them that we're all in this together."
As the team prepared for the Seattle Seahawks, Holland has been on hand for practices and team meetings throughout the week.
"Johnny's doing real well right now," said Shanahan. "He's a part of all our meetings, he comes out to practice when we're outside. It's been great having him around more … I didn't know what multiple myeloma was until Johnny got it. And then once I found out that he got it, then I've seen how many people do have it. So it was cool to bring awareness to it and support him and the cause as much as you can."
The one-of-a-kind sneakers showcase a burgundy ribbon on the shoe's tongue in honor of multiple myeloma awareness. The unique design includes JH initials and the acronym IGYB, which stands for "I've Got Your Back."
To see photos and watch videos of the 49ers 2021 "My Cause My Cleats" campaign, visit www.49ers.com/cleats.