The San Francisco 49ers have announced their 2018 regular season schedule.

The 49ers will take on the NFC North and AFC West in cross-divisional play while continuing to battle their NFC West opponents twice a year. The Niners will open the regular season on the road as they take on the Minnesota Vikings at U.S. Bank Stadium. The team is scheduled to play in five prime time games in 2018, with two on ESPN's Monday Night Football (Week 6 at Green Bay & Week 10 vs. New York Giants), two on NBC's Sunday Night Football (Week 7 vs. Los Angeles Rams & Week 12 at Seattle) and one on FOX/NFL Network's Thursday Night Football (Week 9 vs. Oakland).

A Closer Look at the 2018 Schedule…

• The Niners open the regular season on the road for the first time since 2014 [at Dal. (9/7/14) – W, 28-17].

• This will be the first time San Francisco opens the season with three of their first four games on the road since 2012.

• The 49ers face three teams in 2018 that reached the postseason in 2017 (Kansas City, Los Angeles Rams and Minnesota).

• The Detroit Lions (Week 2) and Oakland Raiders (Week 9) will be making their first visits to Levi's® Stadium.

• San Francisco is scheduled to have five prime time games for the first time since the 2014 season. This marks the first time the 49ers will play three prime time games at home since Levi's® Stadium opened in 2014.
• Following San Francisco's Week 12 matchup at Tampa Bay, the 49ers do not play outside the Pacific time zone for the remainder of the regular season. The last time San Francisco did not travel outside of the Pacific time zone in the month of December was 2014.

Week 1 – Sunday, September 9 at Minnesota – 10:00 a.m. PT on FOX

• The 49ers and Vikings open the season against each other for the first time since the Niners defeated the Vikings, 20-3, to open the 2015 season on ESPN's Monday Night Football.
• The 49ers own a 23-22-1 advantage in the all-time series against the Vikings.
• San Francisco makes their regular season debut in Minnesota's U.S. Bank Stadium, which hosted Super Bowl LII. The 49ers visited the Vikings and U.S. Bank Stadium in Week 3 of the preseason in 2017.

Week 2 – Sunday, September 16 vs. Detroit – 1:05 p.m. PT on FOX

• San Francisco has won each of the past 12 home games against the Lions.
• Detroit's last visit to San Francisco came in 2012, a 27-19 victory for the 49ers.
• The 49ers own the overall series record vs. Detroit, 37-28-1, and are 23-10-1 at home in the series.
• The 49ers have won nine out of their last 10 games against Detroit and 14 out of the last 16 overall.

Week 3 – Sunday, September 23 at Kansas City – 10:00 a.m. PT on FOX

• San Francisco's overall record vs. Kansas City is 7-5 and 2-4 on the road.
• The Niners won the last meeting between the two teams, 22-17, in 2014 at Levi's® Stadium.
• The 49ers look for their first regular season win in Kansas City since 1982.

Week 4 – Sunday, September 30 at Los Angeles Chargers – 1:25 p.m. PT on CBS

• The 49ers and Chargers have split the overall regular season series, with each team registering seven wins.
• The Niners make their debut at StubHub Center, the Chargers temporary home stadium located in Carson, California.
• San Francisco looks for their first regular season win against the Chargers since 2000.

Week 5 – Sunday, October 7 vs. Arizona – 1:25 p.m. PT on FOX

• The 49ers are 17-11 at home vs. the Cardinals and have won six out of their last nine home games vs. Arizona.

Week 6 – Monday, October 15 at Green Bay – 5:15 p.m. PT on ESPN

• This marks the first time the 49ers will face the Packers on Monday Night Football since 11/29/99, and the first time at Lambeau Field on Monday Night Football since 10/14/96.
• San Francisco has won eight consecutive games on Monday Night Football and look to extend the longest streak in franchise history.
• The Niners are 12-3 over their last 15 games on Monday Night Football.
• San Francisco is 30-35-1 in the all-time series vs. Green Bay and 12-23 on the road.
• The Niners have won four out of the last five overall games against the Packers, including each of the last two meetings at Lambeau Field.
• The 49ers travel to Green Bay for the first time since defeating the Packers, 23-20, in the Wild Card round of the 2013 playoffs.

Week 7 – Sunday, October 21 vs. Los Angeles Rams – 5:20 p.m. PT on NBC

• The 49ers and Rams split the season series against the Rams in 2017, with each team winning on the road.
• San Francisco is 7-2-1 in their last 10 meetings at home against the Rams.
• San Francisco leads the all-time series against the Rams, 69-65-3.
• The 49ers look for their first win on NBC's Sunday Night Football since 2013, a 34-3 win over the Houston Texans.
• This marks the team's first game on Sunday Night Football since 2015.

Week 8 – Sunday, October 28 at Arizona – 1:25 p.m. PT on FOX

• San Francisco owns the overall series record vs. Arizona, 29-24.

• The 49ers are looking to win at Arizona for the first time since 2013.

Week 9 – Thursday, November 1 vs. Oakland – 5:20 p.m. PT on FOX/NFL Network

• The Raiders travel across the Bay as they make their first trip to Levi's® Stadium.
• San Francisco has won four of the last six overall matchups between the two teams.
• The Niners and Raiders meet in prime time for only the second time in franchise history, as the 49ers defeated the Los Angeles Raiders, 44-14, on _Monday Night Football _in 1994.
• The 49ers own a 7-6 record on Thursday Night Football as they look for their first win on TNF since defeating the St. Louis Rams, 35-11, in 2013.

Week 10 – Monday, November 12 vs. New York Giants – 5:15 p.m. PT on ESPN

• The 49ers are 12-9 at home in the series and look to defeat the Giants at Levi's® Stadium for the second consecutive season, winning last season's Week 10 matchup 31-21.
• San Francisco has won two of the last three matchups between the two clubs, and each team has registered 20 wins in the all-time series.

Week 11 – Sunday, November 18 – BYE

• This marks the second time in franchise history, and the second consecutive season, that the 49ers have had their BYE in Week 11.

Week 12 – Sunday, November 25 at Tampa Bay – 10:00 a.m. PT on FOX

• The 49ers are 17-6 overall vs. Tampa Bay, including a 5-3 record on the road.
• San Francisco makes their first trip to Tampa Bay since defeating the Buccaneers, 33-14, in 2013.
• The Niners have won four of the past six meetings between the two teams.

Week 13 – Sunday, December 2 at Seattle – 5:20 p.m. PT on NBC

• The 49ers are 7-14 overall on the road at Seattle.
• San Francisco is looking to win at Seattle for the first time since 2011.

Week 14 – Sunday, December 9 vs. Denver – 1:05 p.m. PT on CBS

• San Francisco and Denver are tied in the all-time series with seven wins apiece.
• This marks the Broncos first trip to the Bay Area to take on the 49ers in the regular season since 2002.
• San Francisco's last home game against Denver took place at Wembley Stadium in London, England in 2010, a 24-16 victory for the 49ers.

Week 15 – Sunday, December 16 vs. Seattle – 1:05 p.m. PT on FOX

• San Francisco is 15-24 in the all-time series vs. Seattle and 8-10 at home.
• The Niners have won five of the past nine home games against the Seahawks.

Week 16 – Sunday, December 23 vs. Chicago – 1:05 p.m. PT on FOX

• San Francisco's overall record vs. Chicago is 34-31-1 and 22-13 at home.
• This is the 49ers fourth consecutive regular season meeting against the Bears, and sixth between the teams in the past seven years.
• Chicago returns to Levi's® Stadium for the first time since facing the 49ers in the first regular season game in Levi's® Stadium's history on 9/14/14.
• Last season, San Francisco won on the road in Chicago, 15-14, as QB Jimmy Garoppolo made his first start as a member of the 49ers.

Week 17 – Sunday, December 30 at Los Angeles Rams – 1:25 p.m. PT on FOX

• The 49ers and Rams close out the regular season against one another for the third time in the last four seasons (2015 & 2017).
• The 49ers defeated the Rams at the Los Angeles Memorial Coliseum, 34-13, last season and have won each of their two matchups in Los Angeles against the Rams since their return in 2016.