The San Francisco 49ers announced on Monday that they will square off with the Oakland Raiders in a preseason matchup on Saturday, August 28 at 6 p.m. in Oakland. The entire 49ers preseason and regular season schedules are listed below.
2010 49ERS PRESEASON SCHEDULE **
| Preseason Week | Opponent | Network (Time) |
| Week 1 | @ Indianapolis | CBS-5 (1:00 p.m. PT) |
| Week 2 (Sun, Aug. 22) | vs. Minnesota | NBC (5 p.m. PT) |
| Week 3 | @ Oakland | CBS-5 (6:00 p.m. PT) |
| Week 4 | vs. San Diego | CBS-5 (7:00 p.m. PT) |
