San Francisco 49ers

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San Francisco 49ers 11-4

Indianapolis Colts 8-7

Brock Purdy Named NFC Offensive Player of the Week vs. Colts

San Francisco 49ers quarterback Brock Purdy was named NFC Offensive Player of the Week after the team's Week 16 win over the Indianapolis Colts.

Kittle, McCaffrey, Juszczyk, and Three More 49ers Players Selected to 2026 Pro Bowl Games

FB Kyle Juszczyk, TE George Kittle, RB Christian McCaffrey, T Trent Williams, LB Luke Gifford, and LS Jon Weeks were selected for the 2026 Pro Bowl Games in San Francisco, California.

49ers Light Up 'MNF' Win vs. Colts; 5 Takeaways from #SFvsIND

The San Francisco 49ers finished their Week 16 "Monday Night Football" contest with a 48-27 win over the Indianapolis Colts at Lucas Oil Stadium.

49ers Clinch Playoff Spot Ahead of Week 16 "Monday Night Football"

The San Francisco 49ers have officially clinched a playoff spot for the 2025 NFL postseason.

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'Tis the Season of Giving: 49ers Host Annual 'Hope for the Holidays' Event 🎄

C.J. West Talks First-Career Sack, Recaps Win vs. Indianapolis Colts

Clinched, but Not Finished: 49ers Chase No. 1 Seed and Home-Field Edge

Go Inside the 49ers Locker Room Following Week 16 vs. Colts

Week 16: San Francisco 49ers vs. Indianapolis Colts Highlights

Go Inside the 49ers Locker Room Following Week 16 vs. Colts

Get an inside view of the 49ers locker room following the team's Week 16 win over the Colts presented by Ticketmaster.

San Francisco 49ers Top Plays vs. Colts | Week 16

Watch the best plays by the San Francisco 49ers against the Indianapolis Colts in Week 16 of the 2025 NFL season.

George Kittle's Best Plays from 115-Yard Game vs. Colts | Week 16

San Fransisco TE George Kittle marked seven receptions for 115 yards and a TD vs. the Indianapolis Colts on "Monday Night Football."

Brock Purdy's Best Plays from 5-TD Game vs. Colts | Week 16

San Francisco 49ers QB Brock Purdy threw a career-high five touchdown passes in his team's Week 16 win over the Indianapolis Colts.

Christian McCaffrey's Best Plays from 146-Yard Game vs. Colts | Week 16

San Francisco 49ers RB Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns Monday Night vs. the Indianapolis Colts.

C.J. West Talks First-Career Sack, Recaps Win vs. Indianapolis Colts

San Francisco 49ers DL C.J. West reflected on his first-career sack and shared his reaction to the 49ers "Monday Night Football" win over the Indianapolis Colts, presented by Lexus.

Pick-Six Alert: Dee Winters 74-Yard TD vs. Colts

San Francisco 49ers LB Dee Winters intercepted Indianapolis Colts QB Philip Rivers and returned it 74 yards for a pick-six.

Collins Brings Down Rivers, Causes Fumble for 15-Yard Loss

San Francisco DL Alfred Collins sacks Colts QB Philip Rivers, forcing a fumble that results in a 15-yard loss in the team's Week 16 matchup.

Christian McCaffrey Adds Second TD to 49ers 'MNF' Lead

San Francisco 49ers RB Christian McCaffrey catches a 9-yard touchdown pass from QB Brock Purdy, marking his second TD of the night.

McCaffrey's 24-Yard Run Marks His Longest Carry of 2025

San Francisco 49ers RB Christian McCaffrey raced out of the backfield for a 24-yard gain, marking his longest carry of the 2025 season.

Brock Purdy's Fourth TD Pass of Night Goes to Jennings

San Francisco QB Brock Purdy throws his fourth touchdown of the night to WR Jauan Jennings.

Brock Purdy Threads 21-Yard Pass to Jennings vs. Colts

San Francisco 49ers QB Brock Purdy delivered a precise 21-yard pass to WR Jauan Jennings as the 49ers move the ball downfield against Indianapolis.

Brock Purdy Finds Skyy Moore for 23-Yard Gain vs. Colts

San Francisco 49ers QB Brock Purdy completed a 23-yard pass to WR Skyy Moore in the team's Week 16 matchup.

C.J. West Brings Down Rivers, Notches First-Career Sack

San Francisco DT C.J. West bursts through the line to sack Colts QB Philip Rivers for an 8-yard loss.

Kittle Hauls in Purdy's Third Touchdown

San Francisco 49ers TE George Kittle secured an 11-yard touchdown reception from QB Brock Purdy, giving the 49ers momentum against Indianapolis.

McCaffrey Dazzles With Stutter Step on 18-Yard Gain

San Francisco 49ers RB Christian McCaffrey flashed his quickness on an 18-yard rush as the 49ers move the chains.

McCaffrey's 15th TD of 2025 Puts 49ers Ahead of Colts

San Francisco 49ers RB Christian McCaffrey catches a 2-yard touchdown pass from QB Brock Purdy in the team's Week 16 matchup against the Indianapolis Colts.

Abdullah Fumbles, Tonges Comes Up With Recovery

San Francisco 49ers TE Jake Tonges recovered a fumble after Indianapolis Colts RB Ameer Abdullah lost control, giving the 49ers a key takeaway.

Purdy Airs It Out for 22-Yard TD to Robinson

San Francisco 49ers QB Brock Purdy connected with WR Demarcus Robinson on a 22-yard touchdown in the team's Week 16 matchup against the Indianapolis Colts.

Chicago Bears

🗓️ December 28th, 2025
⏰ 5:20 PM

Seattle Seahawks

🗓️ January 4th, 2026
⏰ TBD

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49ers Give Back at Annual Hope for the Holidays Event 🎄

San Francisco 49ers staff, players and their families came together to share the holiday spirit, supporting 175 underserved families at a drive-through distribution in the Levi's® Stadium parking lot, presented by U.S. Bank.

49ers Celebrate Postgame Following 48-27 Win Over Colts🎊

View postgame photos following the San Francisco 49ers Week 16 matchup vs. the Indianapolis Colts.

Lucas Oil Stadium Shakes as the Faithful Show Up

View photos of 49ers fans during the team's Week 16 game against the Indianapolis Colts.

San Francisco 49ers vs. Indianapolis Colts Game Highlights

View game photos from the San Francisco 49ers Week 16 matchup vs. the Indianapolis Colts at Lucas Oil Stadium.

49ers Clinch Playoffs & Celebrate the Holidays | The Saloon

ESPN's MJ Acosta-Ruiz joins 49ers team reporter Briana Jeannel to recap the 49ers Week 16 "Monday Night Football" win, with one-on-one interviews featuring San Francisco 49ers S Malik Mustapha and DL C.J. West, plus the 49ers answer holiday themed questions.

49ers Players on Team's Mindset: 'Just Handle Business Each Week'

San Francisco 49ers QB Brock Purdy, TE George Kittle, RB Christian McCaffrey, T Trent Williams, and LB Dee Winters highlighted team chemistry, preparation, and the importance of staying focused as the 49ers look ahead to the playoffs.

Shanahan: "Proud of How the Team Played All Year" | 49ers

San Francisco 49ers head coach Kyle Shanahan reflected on the 49ers journey this season, emphasizing consistency, leadership, and the players' ability to overcome injuries and adversity to secure a crucial win.

Shanahan Provides Injury Updates on Pearsall Ahead of Colts Game | Press Pass

San Francisco 49ers head coach Kyle Shanahan addressed WR Ricky Pearsall's status and shared the latest injury updates as the team prepares for Monday's matchup against the Indianapolis Colts.

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49ers players spent the evening at Levi's® Stadium giving back to the community, providing food and gifts to families during the “Hope for the Holidays” event presented by U.S. Bank.

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'Tis the Season of Giving: 49ers Host Annual 'Hope for the Holidays' Event 🎄

49ers players spent the evening at Levi's® Stadium giving back to the community, providing food and gifts to families during the “Hope for the Holidays” event presented by U.S. Bank.

San Francisco 49ers staff, players and their families came together to share the holiday spirit, supporting 175 underserved families at a drive-through distribution in the Levi's® Stadium parking lot, presented by U.S. Bank.

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49ers Give Back at Annual Hope for the Holidays Event 🎄

San Francisco 49ers staff, players and their families came together to share the holiday spirit, supporting 175 underserved families at a drive-through distribution in the Levi's® Stadium parking lot, presented by U.S. Bank.

Smiles filled Levi's® Stadium as San Francisco 49ers QB Brock Purdy surprised families with Toyota vehicles, Rivalries jerseys, and tickets to an upcoming 49ers game, presented by Ticketmaster

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Brock Purdy Creates Unforgettable Moments for Families

Smiles filled Levi's® Stadium as San Francisco 49ers QB Brock Purdy surprised families with Toyota vehicles, Rivalries jerseys, and tickets to an upcoming 49ers game, presented by Ticketmaster

San Francisco 49ers QB Brock Purdy surprised families with incredible holiday gifts, including Toyota vehicles, Rivalries jerseys, and tickets to an upcoming 49ers game, creating unforgettable moments for all, presented by Toyota.

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Brock Purdy Surprises Families with Unforgettable Holiday Gifts

San Francisco 49ers QB Brock Purdy surprised families with incredible holiday gifts, including Toyota vehicles, Rivalries jerseys, and tickets to an upcoming 49ers game, creating unforgettable moments for all, presented by Toyota.

49ers Home | San Francisco 49ers – 49ers.com

Brock Purdy Named NFC Offensive Player of the Week vs. Colts

Kittle, McCaffrey, Juszczyk, and Three More 49ers Players Selected to 2026 Pro Bowl Games

49ers Light Up 'MNF' Win vs. Colts; 5 Takeaways from #SFvsIND

49ers Clinch Playoff Spot Ahead of Week 16 "Monday Night Football"

'Tis the Season of Giving: 49ers Host Annual 'Hope for the Holidays' Event 🎄

C.J. West Talks First-Career Sack, Recaps Win vs. Indianapolis Colts

Clinched, but Not Finished: 49ers Chase No. 1 Seed and Home-Field Edge

Go Inside the 49ers Locker Room Following Week 16 vs. Colts

Week 16: San Francisco 49ers vs. Indianapolis Colts Highlights

Go Inside the 49ers Locker Room Following Week 16 vs. Colts

San Francisco 49ers Top Plays vs. Colts | Week 16

George Kittle's Best Plays from 115-Yard Game vs. Colts | Week 16

Brock Purdy's Best Plays from 5-TD Game vs. Colts | Week 16

Christian McCaffrey's Best Plays from 146-Yard Game vs. Colts | Week 16

C.J. West Talks First-Career Sack, Recaps Win vs. Indianapolis Colts

Pick-Six Alert: Dee Winters 74-Yard TD vs. Colts

Collins Brings Down Rivers, Causes Fumble for 15-Yard Loss

Christian McCaffrey Adds Second TD to 49ers 'MNF' Lead

McCaffrey's 24-Yard Run Marks His Longest Carry of 2025

Brock Purdy's Fourth TD Pass of Night Goes to Jennings

Brock Purdy Threads 21-Yard Pass to Jennings vs. Colts

Brock Purdy Finds Skyy Moore for 23-Yard Gain vs. Colts

C.J. West Brings Down Rivers, Notches First-Career Sack

Kittle Hauls in Purdy's Third Touchdown

McCaffrey Dazzles With Stutter Step on 18-Yard Gain

McCaffrey's 15th TD of 2025 Puts 49ers Ahead of Colts

Abdullah Fumbles, Tonges Comes Up With Recovery

Purdy Airs It Out for 22-Yard TD to Robinson

Walter Payton Man of the year

49ers Internship Program

Faithful Appreciation Week | Week 18 vs. Seahawks

Chicago Bears

Seattle Seahawks

49ers Give Back at Annual Hope for the Holidays Event 🎄

49ers Celebrate Postgame Following 48-27 Win Over Colts🎊

Lucas Oil Stadium Shakes as the Faithful Show Up

San Francisco 49ers vs. Indianapolis Colts Game Highlights

49ers Clinch Playoffs & Celebrate the Holidays | The Saloon

49ers Players on Team's Mindset: 'Just Handle Business Each Week'

Shanahan: "Proud of How the Team Played All Year" | 49ers

Shanahan Provides Injury Updates on Pearsall Ahead of Colts Game | Press Pass

'Tis the Season of Giving: 49ers Host Annual 'Hope for the Holidays' Event 🎄

49ers Give Back at Annual Hope for the Holidays Event 🎄

Brock Purdy Creates Unforgettable Moments for Families

Brock Purdy Surprises Families with Unforgettable Holiday Gifts

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